Playmouse is a media group that specializes in sexy entertainment, with a television channel and two print magazines called Playmouse and Pentmouse. Its main stars are Melissa and Clarissa, a pair of mice who had independent modelling careers before joining up and creating one of the most popular names in adult entertainment.

Playmouse and its stars are mentioned in several places throughout the Zoniverse, most prominently with Melissa and Clarissa appearing on the 2110 series of Friday Night Party in Friday Night Party - Melissa vs Clarissa.

After the girls were gunged on Friday Night Party, the Playmouse crew ran with the popularity of gunge and added a "Gunk Dunk" feature to their own yearly celebration where Clarissa was seated nude above a vat of green slime and was tipped in when their donation goal was met.

Playmouse was an actual furry art gallery in the early 2000s, prominently contributed to by DAQ, Ixbalam and Catsnightmare.